Ireland centre Robbie Henshaw will miss the rest of the Six Nations after injuring his shoulder in the 56-19 win over Italy in Dublin on Saturday.
Henshaw left the pitch with his shoulder in a sling after picking up the injury when he landed awkwardly while scoring his second try.
The Irish Rugby Football Union (IRFU) said in a statement that the player had undergone a procedure on his shoulder and had been ruled out of the remaining three matches of the campaign.
Prop Tadhg Furlong, who suffered a minor hamstring injury against Italy, underwent a scan but was expected to be fit for the game against Wales in Dublin on Feb. 24.
Henshaw's absence is a big loss for Ireland who are already without Garry Ringrose, who is making good progress in his recovery from an ankle injury and not far off a return, in midfield.
Ireland are level on points with holders England at the top of the Six Nations standings after wins over France and Italy.