South Africa back Jesse Kriel has been ruled out of the rest of the Springboks' European tour after suffering a lower leg injury against the Barbarians, the South African Rugby Union said on Sunday.
Kriel, who suffered the injury in Saturday's 31-31 draw at Wembley, is replaced by Lions centre Rohan Janse van Rensburg for the Tests against England, Italy and Wales.
South Africa have also added wing Jamba Ulengo to the squad as cover for players suffering from knocks, a team statement added.
The Boks play England at Twickenham on Saturday, after which they meet Italy in Florence on November 19 and Wales in Cardiff on November 26.
New Zealand has their own injury concerns, with centres Ryan Crotty and George Moala casualties from their loss to Ireland.
Moala (elbow) will be replaced in the squad by Seta Tamanivalu, who has been in England with the Barbarians.
Crotty will remain with the All Blacks as he vies to overcome a hamstring strain.