Former Wallabies captain James Horwill had a yo-yoing night for Harlequins, in their 35-28 win over Bath.
Horwill crashed over for a 45th minute try to give his side a 33-6 lead in the second half, before being handed a yellow card with three minutes left in the match.
George Smith will start at openside for Wasps when they take on Leicester on Saturday night (AEDT).
Smith will take on capped Wallaby Peter Betham, with Betham starting at outside centre for the Tigers.
The Wasps are the form team in the Premiership after winning seven of their last eight games.
Capped Wallabies winger Cooper Vuna will line up on the left wing for Worcester against Gloucester.
Adam Ashley-Cooper continued his roller coaster ride with Bordeaux in a 13-13 draw against Toulouse.
The Wallabies winger was yellow-carded in the 58th minute of the draw, after scoring a hat-trick a week earlier.
Prop Sekope Kepu came on at half-time for Bordeaux in the match.
Drew Mitchell will once again be the sole Wallaby representative in Toulon’s lineup, when they take on Grenoble.
Mitchell will start on the wing, with James O’Connor (illness), Quade Cooper (sevens) and Matt Giteau (groin) unavailable for the match.
Peter Kimlin will start at lock for Grenoble at Stade Mayol.
Montpellier takes on Oyonnax to complete the round on Monday morning (AEDT).