Wallaroos Lori Cramer and Ash Marsters will return to action as the Queensland Reds host the Western Force at Ballymore on Saturday.
Cramer has been thrown straight into the starting side as a fullback after arriving from England and finishing her stint at Exeter.
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She is one of several changes to the Reds’ side that defeated the ACT Brumbies 45-15 last week, including Layne Morgan's club debut.
Morgan relocated from the NSW Waratahs at the start of the year and partners with Carys Dallinger in the halves.
Newly appointed co-captains Jemma Bemrose and Ivania Wong lead the way against a Force side that has named Wallaroos all-time cap leader Marsters for her debut.
Marsters will come off the bench, able to cover all positions, whilst Wallaroos skipper Michaela Leonard starts in the second row.
Trileen Promare, who was once again appointed captain, partners fellow Wallaroo Cecilia Smith in the midfield, whilst former Brumby Allana Sikimeti makes her first start for the Force.
Leonard is joined by Australia A rep Rosie Ebbage in the second-row, with former Waratah Sera Naiqama to come off the bench.
In Sydney, backrower Emily Chancellor continues her recovery from injury as she captains the Waratahs against the ACT Brumbies.
Young gun Waiaria Ellis switches to flyhalf after their draw with the Blues, allowing Caitlyn Halse to return to fullback.
Halse is one of several Wallaroos in the starting side, including winger Desiree Miller and centre Georgina Friedrichs
As for the ACT Brumbies, Fijian international Ana Naimasi will start on the wing for the first time in Brumbies colours.
She forms a strong backline alongside breakout star Faitala Moleka and Biola Dawa, with former Wallaroo Jay Huriwai on the bench.
In the forwards, Tabua Tuinakauvadra is one of five capped Test players alongside captain Siokapesi Palu, Sally Fuesaina, Tania Naden and Lydia Kavoa.
