Leigh Halfpenny, Ken Owens and Justin Tipuric are in line to make their comebacks for Wales in their November internationals more than a year after they last appeared for their country.
But five-eighth Dan Biggar and back Liam Williams miss out because of injury.
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Biggar has been captain this year, replacing the then-injured Alun Wyn Jones. Jones is back but not guaranteed to be skipper as he is not a certain starter.
Coach Wayne Pivac said on Tuesday he would make a decision after this weekend's round of club rugby.
"There'll be a captain for the series, but there might be more than one as few players play four tests," he added.
The New Zealander named a 35-man selection, made up of 20 forwards and 15 backs.
There are five uncapped players with a promotion from the under-20 side for Joe Hawkins, a return for uncapped Josh Macleod and first call-ups for Dane Blacker, Sam Costelow and Rio Dyer.
"It's great to have Ken, Justin and Leigh back after long-term injuries," Pivac said.
"They are three great players who have served Wales very well. They are all British & Irish Lions, so quality players. We're excited to have them in the squad for obvious reasons. We have a number of young players in this squad so it will be great for them to rub shoulders with these experienced ones."
Pivac said the new inclusions were an eye not only on next year's World Cup but the tournament after that.
"There's a lot of young players we've been keeping an eye on for a number of years through the age group system and now playing club rugby," he added.
"There's a view of the here and now in this squad, but also beyond Rugby World Cup 2023 to the tournament in 2027, so there's some young guys getting the opportunity to taste the camp environment. They may or may not get game time, but it will be a great experience for them."
Also returning are Jac Morgan and Rhys Priestland, who were last called up for the Six Nations at the start of the year, loosehead props Rhodri Jones and Nicky Smith for the first time since the 2021 mid-year matches campaign and Christ Tshiunza, who made his senior international debut last November.
Wales will play test matches on four consecutive Saturdays in November against New Zealand, Argentina, Georgia and Australia at Cardiff's Principality Stadium.
Wales Squad
Forwards: Adam Beard (Ospreys), Ben Carter (Dragons), Ryan Elias (Scarlets), Taulupe Faletau (Cardiff), Alun Wyn Jones (Ospreys), Rhodri Jones (Dragons), Dewi Lake (Ospreys), Dillon Lewis (Cardiff), Dan Lydiate, Josh MacLeod, Jac Morgan (all Ospreys), Ken Owens (Scarlets), Tommy Reffell (Leicester Tigers), Will Rowlands (Dragons Rugby), Nicky Smith, Gareth Thomas, Tomas Francis, Justin Tipuric (all Ospreys), Christ Tshiunza (Exeter Chiefs), Sam Wainwright (Saracens)
Backs: Josh Adams (Cardiff), Gareth Anscombe (Ospreys), Dane Blacker, Sam Costelow (both Scarlets), Alex Cuthbert (Ospreys), Rio Dyer (Dragons), Leigh Halfpenny, Kieran Hardy (both Scarlets), Joe Hawkins, George North (both Ospreys), Rhys Priestland (Cardiff), Louis Rees-Zammit (Gloucester), Nick Tompkins (Saracens), Owen Watkin (Ospreys), Tomos Williams (Cardiff).
