Wales coach Warren Gatland has named uncapped flanker James Davies and winger Josh Adams in his 39-man squad for the Six Nations championship.
Davies, brother of experienced Wales centre Jonathan Davies, has been in consistent form for Scarlets and Worcester Warriors' Adams has scored 11 tries this season.
No.8 Taulupe Faletau, winger George North and five-eighth Rhys Priestland were selected despite being injured while flanker Ross Moriarty has also been called up after returning from a lengthy injury lay-off this month.
"James's form over the last couple of years has been impressive, he's in a competitive area but we look forward to seeing what he can do," Gatland said. "For Josh it's a great opportunity, he's been on great form.
"We have included a couple of players who are carrying injuries ... It's useful to have these experienced guys around camp and to have them included and to work with them.
Alun Wyn Jones will captain the side but veterans Luke Charteris, Gethin Jenkins and Jamie Roberts missed out along with injured back-row forwards Sam Warburton and Dan Lydiate.
Wales won two of their four November internationals against Georgia and South Africa, losing to New Zealand and Australia.
Gatland's side face Scotland in their opening Six Nations match in Cardiff on February 3.
Wales Six Nations squad
Alun Wyn Jones (capt)