Ben Tapuai’s Bath completed a sensational win over Saracens, overcoming the powerhouses 31-21.
Bath were down to 14 men after injuries and trailed the star-studded opposition late in the game, before two tries in the final five minutes sealed a shock victory.
Rob Horne’s Northampton took the bragging rights over Matt Toomua's Leicester, bouncing back from a disappointing opener, with both centres playing the full match.
Nic White and Dave Dennis had a big win with Exeter, over promoted side London Irish, with fullback Lachie Turner coming on in the final 17 minutes.
James Horwill’s Harlequins had a win over Gloucester, 28-17, with the former Wallabies skipper playing the entire 80 in the second row.
Sale 12 - Newcastle 13
Bath 31 - Saracens 21
Exeter 37 - London Irish 7
Harlequins 28 - Gloucester 17
Northampton 24 - Leicester 11
Worcester 10 - Wasps 24
David Pocock crossed for a try as Panasonic continued an emphatic start to the year, with a 64-17 win over Coca-Cola
Digby Ioane was yellow-carded in the win, while former Wallabies lock Daniel Heenan came on in the second half.
Adam Ashley-Cooper came off the bench to play the last 17 minutes for Kobe Steel in their big win over the NEC Green Rockets.
George Smith played out the game at openside for Suntory in another big win for the defending champions, 36-11 over NTT Communications Shining Arcs.
Anthony Faingaa played the opening 35 minutes for Kintetsu, with the Liners going on to take a tight 25-20 win over Canon.
NEC Green Rockets 12 - Kobelco Steelers 29
Kubota spears 27 - Toyota Industries Shuttles 19
Suntory 36 - Shining Arcs 11
Yamaha 35 - Ricoh Black Rams 12
NTT Docomo Red Hurricanes 29 - Munakata Sannyx Blues 19
Toyota Verblitz 23 - Toshiba brave Lupus 18
Kintetsu Liners 25 - Canon Eagles 20
Coca-Cola Red Sparks 17 - Panasonic 64
Peter Betham came off the bench and crossed for Clermont in the 66th minute as the French champions were stunned by La Rochelle, with former Wallabies lock Sitaleki Timani playing 70 minutes of the match.
Leroy Houston helped Bordeaux to a dominant 30-10 win over Stade Francais, starting at the back of the scrum.
Joe Tomane played at inside centre as Montpellier edged out Castres, 22-17, with a try in the 75th minute sealing their win.
Liam Gill was at seven for Lyon, going down to Pau 30-14.
La Rochelle 51 - Clermont 20
Bordeaux 30 - Stade Francais 10
Oyonnax 12 - Agen 10
Brive 6 - Racing 92 25
Castres 17 - Montpellier 22
Toulon 20 - Toulouse 16
Scott Fardy played in the second row for Leinster for the second week in a row, as the Irish powerhouse beat Cardiff 37-9.
Christian Lealiifano steered Ulster for 61 minutes, playing at flyhalf in a narrow 21-14 win.
Former Super Rugby sides, the Cheetahs and the Kings, both suffered heavy losses for the second week.
Leinster 37 - Cardiff 9
Edinburgh 35 - Newport Gwent Dragons 18
Glasgow 31 - Ospreys 10
Benetton 14 - Ulster 21
Munster 51 - Cheetahs 18
Zebre 10 - Scarlets 41
Connacht 32 - Kings 10