Tomas Cubelli will step into the starting scrumhalf role for the Brumbies on Friday night, replacing Joe Powell in the XV.
Cubelli came off the bench last week against the Reds, three days after returning from Argentina, scoring a try in his stint on the field.
Brumbies coach Stephen Larkham said earlier on Wednesday that it was a return to a formula that worked before the Test window.
"It was very difficult for him (Tomas) but he played a really good game both defensively and in attack and this week we're going to make a change and put Tomas in the starting team,” he said.
“Joey will do a similar role what he's been doing for the whole season, coming off the bench and adding a little bit of impact and shoring up our defence."
In the only other change to the starting team, Michael Wells comes into the number eight spot, in place of injured backrower Ben Hyne.
Hyne suffered a season-ending ankle injury just four minutes into his Super Rugby debut, against the Reds.
Brumbies team to take on the Blues on Friday night at 5:35pm AEST
1. Scott Sio
2. Stephen Moore (c)
3. Ben Alexander
4. Rory Arnold
5. Sam Carter
6. Scott Fardy
7. Jarrad Butler
8. Michael Wells
9. Tomás Cubelli
10. Christian Lealiifano (c)
11. James Dargaville
12. Matt Toomua
13. Tevita Kuridrani
14. Nigel Ah Wong
15. Aidan Toua
RESERVES
16. Josh Mann-Rea
17. Allan Alaalatoa
18. Ruan Smith
19. Blake Enever
21. Tom Staniforth
22. Joe Powell
23. Andrew Smith
24. Lausii Taliauli
