There'll be no Brisbane Broncos reunion at Suncorp Stadium on Saturday night, with Ben Te'o left out of the England side to face the Wallabies.
Eddie Jones has opted to bring Luther Burrell into the inside centre spot for the match, partnering with Jonathan Joseph.
Jones has also moved to bring Owen Farrell into the flyhalf spot, pushing George Ford out of the starting team.
Superstar lock Maro Itoje will remain in the second row, after speculation about a potential move into the back row.
The most surprising selection is the naming of Marland Yarde on the wing.
England coach Jones said a win in this Saturday's first Test would be hugely significant for his side, in a city where England has never won.
“If you look at England’s record in Australia it’s pretty ordinary," he said.
"We’ve only ever won three games in Australia so it’s a great opportunity to put down a marker and create history. It’s important we get off to a positive start and we’ll arrive in Brisbane ready to play physical and aggressive rugby.It’ll be a great challenge for us and one we’re looking forward to meeting head on
“We’re excited to be playing against a strong Australian team in their backyard. The Wallabies are ranked second in the world and have the World Rugby coach of the year, so that’s why they start as favourites. There’s a lot of expectation on them to win the series convincingly.
“We have a young squad with an average age of 24 so we are still developing and improving. It’ll be a great challenge for us and one we’re looking forward to meeting head on.”
England team to face Wallabies, Saturday June 11, 8:00pm AEST
1. Mako Vunipola (Saracens, 32 caps)
2. Dylan Hartley (captain, Northampton Saints, 72 caps)
3. Dan Cole (Leicester Tigers, 62 caps)
4. Maro Itoje (Saracens, 4 caps)
5. George Kruis (Saracens, 15 caps)
6. Chris Robshaw (Harlequins, 48 caps)
7. James Haskell (Wasps, 68 caps)
8. Billy Vunipola (vice captain, Saracens, 26 caps)
9. Ben Youngs (Leicester Tigers, 58 caps)
10. Owen Farrell (vice captain, Saracens, 40 caps)
12. Luther Burrell (Northampton Saints, 14 caps)
13. Jonathan Joseph (Bath Rugby, 22 caps)
15. Mike Brown (vice captain, Harlequins, 49 caps)
16. Luke Cowan-Dickie (Exeter Chiefs, 3 caps)
17. Matt Mullan (Wasps 10 caps)
18. Paul Hill (Northampton Saints, 2 cap)
19. Joe Launchbury (Wasps, 32 caps)
20. Courtney Lawes (Northampton Saints, 46 caps)
21. Danny Care (Harlequins, 59 caps)
22. George Ford (Bath Rugby, 23 caps)
23. Jack Nowell (Exeter Chiefs, 15 caps)