Rory Lamont is set to be sidelined for up to four months with a broken leg, the Scottish Rugby Union says.
Scotland wing Lamont was injured during the first half of Scotland's 23-17 defeat by France in Sunday's Six Nations international at Murrayfield when, after jumping to contest a re-start with French number eight Louis Picamoles, he landed awkwardly.
After receiving treatment for several minutes, he was stretchered off.
Glasgow's Lamont has since undergone surgery and Scotland team doctor James Robson told www.scottishrugby.org on Tuesday: "Rory is comfortable. His convalescence will get under way at once.
"Injuries of this nature require typically three to four months of rehabilitation. We all wish Rory a speedy recovery."
Lamont was replaced by Nick de Luca at Murrayfield, where Scotland, despite a much improved display, suffered their third straight defeat in as many Six Nations matches this season and fifth loss in a row in total.
Scotland conclude the Six Nations with potentially tricky away fixtures against Ireland and Italy next month.
Lamont was not the only Scotland player hurt in a physically demanding encounter with World Cup finalists France.
His brother Sean suffered an abrasion to his right eye while Sean's fellow centre Graeme Morrison injured his knee.
Arguably the two most influential injuries Scotland suffered on Sunday, in terms of their hopes of beating France, saw half-backs Mike Blair (dead leg) and Greig Laidlaw (suspected concussion) forced off either side of half-time.
Meanwhile forwards John Barclay, Richie Gray and Jim Hamilton all suffered leg injuries, although none are thought to be serious.
Scotland's next Six Nations match is in Dublin on March 10 when they will face an Ireland side who thrashed Italy 42-10 at Lansdowne Road on Saturday.