The Wallaroos will look to create history as they open the WXV Global Series against England in Manchester.
The Aussies are looking for their maiden win over England in a rematch of last year's World Cup match.
Watch every second of the Wallaroos WXV Global Series live and on demand via Stan Sport.
Winger Amelia Whitaker comes in for her debut, with Jemma Bemrose also set for her maiden Test via the bench.
They face an England side who are ranked number one in the world after sweeping through the Six Nations.
The Red Roses have not lost a game in close to four years, looking to continue their world record unbeaten streak.
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Welcome to Rugby.com.au's coverage of the Wallaroos' clash with England in Manchester.
A packed out crowd is expected at the home of the Sale Sharks, welcoming the Red Roses for the first time ever.
The Wallaroos are very familiar with the ground after last year's 73-0 win over Samoa to kick off their World Cup campaign, and they'll need a massive performance to take down the best in the world.
Conditions are forecast to be cloudy but hopefully dry throughout the 80 minutes, with a little bit of rain around the area.
England (15-1): Ellie Kildunne, Mia Venner, Megan Jones (c), Tatyana Heard, Claudia Moloney-MacDonald, Holly Aitchison, Natasha Hunt, Maddie Feaunati, Sadia Kabeya, Abi Burton, Lilli Ives Campion, Delaney Burns, Sarah Bern, May Campbell, Mackenzie Carson
Replacements: Bryony Field, Hannah Botterman, Maud Muir, Morwenna Talling, Marlie Packer, Lucy Packer, Zoe Harrison, Helena Rowland.
Wallaroos (15-1): Caitlyn Halse, Amelia Whitaker, Georgina Friedrichs, Faitala Moleka, Desiree Miller, Waiaria Ellis, Samantha Wood, Siokapesi Palu Sekona, Lily Bone, Pia Tapsell, Kaitlan Leaney, Michaela Leonard, Faliki Pohiva, Brittany Merlo, Brianna Hoy
Replacements: Tania Naden, Allana Sikimeti, Eva Karpani, Jemma Bemrose, Piper Duck, Emily Chancellor, Tia Hinds, Cecilia Smith
The Red Roses' clash with the Wallaroos will be shown LIVE on Stan Sport.
Coverage will be live and ad-free on Stan Sport, slated to start at 11:50 pm (AEST) with kickoff expected at midnight.
