The Wallabies are set for their sixth different midfield partnership in seven Tests after confirmation that Isaac Henry will miss the rest of the season.
Henry suffered a hamstring injury during the defeat to England last weekend and came off in the 58th minute.
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“Isaac Henry has been ruled out of the remainder of the November Nations Championship Tests after straining his hamstring against England in yesterday’s Test in London,” a statement from the Wallabies said on Tuesday.
The team confirmed that no replacement will join the squad, backing the options they have.
Henry's departure continues the trend of centre swaps in 2026 as a result of injury and suspension
The last time the Wallabies started the same centre pairing in back-to-back Tests was in August, when Paisami and Henry started in wins over Japan and Argentina.
Len Ikitau and Joseph-Aukuso Suaalii returned for the second Test draw against Argentina, with the quartet swapping and changing throughout the South African and Bledisloe Tests.
Ikitau and Suaalii and are the most likely pairing to face Scotland on Monday (AEDT), with Suaalii enjoying stints on the wing.
Kiss could turn to the versatile Filipo Daugunu, who replaced Henry during the England defeat.
Daugunu started twice in 2026 for the Reds at inside centre, whilst also featuring at outside in 2024.
Kurtley Beale is the other primary centre cover in the squad after Paisami withdrew for personal reasons.
If selected, it would be Beale’s first Test since 2021, starting at fullback against Wales.
It shapes as one of several potential changes for the match at Murrayfield as the Wallabies look to end their three-match losing streak.
Carter Gordon and Tom Hooper will both loom for a return, labelled as ‘very close’ to playing last weekend.
Brandon Paenga-Amosa also missed last week due to injury, with Kiss forecasting changes after the loss.
“We'll look at every aspect of our selection process and go through that for sure. The nature of competition for places is exactly what you need, so we need to create that competition as well through those mechanisms, so we may see some things there,” Kiss said.
Hunter Paisami & Isaac Henry - first Argentina Test
Len Ikitau & Joseph-Aukuso Suaalii - second Argentina Test
Hunter Paisami & Len Ikitau - Springboks Test
Len Ikitau & Isaac Henry - first Bledisloe Test
Isaac Henry & Joseph-Auksuo Suaalii - second Bledisloe Test
Len Ikitau & Isaac Henry - England Test