2025 Wallaroos Player of the Year Tabua Tuinakauvadra is set for her first Test appearance of the year against France on Sunday morning (AEST) in Aix-en-Provence.
Tuinakauvadra is one of four personnel changes to the team that went down to England, including the potential debut of Queensland Reds winger Piper Flynn.
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Reds teammates Tiarah Minns and Ava Wereta also join the squad as they look to secure back-to-back wins over France.
The Brumbies number eight will come off the bench as part of a revamped back-row unit, with Piper Duck starting in place of Lily Bone, who failed her HIA.
Further changes to the pack include elevating Allana Sikimeti to the starting front row, joined by Brittany Merlo and Faliki Pohiva.
The backline is unchanged, with last week's debutant Amelia Whitaker cleared of a hamstring injury that saw her taken off early.
Meanwhile, 23-year-old Flynn is set to become the Wallaroos' latest debutant, having flourished since her move to the 15-a-side format.
The flyer made her Super Rugby Women's debut last year against the Brumbies, scoring with her first touch and earning selection for Australia A against Samoa.
“We've landed to warm weather and real anticipation for this Test. We know exactly where our strengths and weaknesses lie, and sharpening those areas week after week is exactly the kind of environment we thrive in," Director of Women's High Performance Tim Walsh said.
“It's about winning the moments in front of us, building something bigger than ourselves, and loving the work it takes to get there.
"France are a complete side, both physical, flamboyant and we're not underestimating anything about what's coming.
"The squad will also welcome another debutant to the international stage this weekend, with Reds speedster Piper Flynn set to earn her first cap."
Wallaroos squad member Hera-Barb Malcolm Heke has returned home to Australia after picking up a knee injury at training that will rule her out for the remainder of the series.
Sunday September 20: Stade Maurice David, Aix-en-Provence - 1:45am AEST
1. Allana Sikimeti - #212 (Western Force/Norths Eagles Rugby) – 5 caps
2. Brittany Merlo - #230 (NSW Waratahs/Sydney University) – 5 caps
3. Faliki Pohiva - #219 (NSW Waratahs/Blacktown Scorpions) – 12 caps
4. Kaitlan Leaney - #179 (NSW Waratahs/SCU Marlins) – 41 caps
5. Michaela Leonard - #168 (Western Force/Tuggeranong Vikings) – 48 caps
6. Pia Tapsell - #236 (Western Force/North Shore Rugby Club) – 2 caps
7. Piper Duck - #185 (NSW Waratahs/Tumut Bullettes) – 28 caps
8. Siokapesi Palu Sekona (c) - #194 (ACT Brumbies/Rockdale Rangers) – 29 caps
9. Samantha Wood - #207 (Western Force/Kalamunda Rugby) – 17 caps
10. Waiaria Ellis - #225 (NSW Waratahs/Blacktown Scorpions) – 8 caps
11. Desiree Miller - #204 (NSW Waratahs/Eastern Suburbs) – 29 caps
12. Faitala Moleka - #199 (ACT Brumbies/Blacktown Scorpions) – 32 caps
13. Georgina Friedrichs - #178 (NSW Waratahs/Wests Bulldogs) – 43 caps
14. Amelia Whitaker - #237 (NSW Waratahs/Randwick) – 1 cap
15. Caitlyn Halse - #210 (NSW Waratahs/Camden Rams) – 16 caps
Reserves
16. Tania Naden - #197 (ACT Brumbies/Uni-North Owls) – 31 caps
17. Brianna Hoy - #203 (NSW Waratahs/Coffs Harbour Snappers) – 15 caps
18. Eva Karpani - #171 (Queensland Reds/Southern Suburbs) – 47 caps
19. Tiarah Minns - #217 (Queensland Reds/Melbourne University) – 6 caps
20. Tabua Tuinakauvadra - #200 (ACT Brumbies/Orange Emus) – 22 caps
21. Tia Hinds - #222 (NSW Waratahs/Randwick) – 12 caps
22. Piper Flynn* (Queensland Reds/Surfers Paradise Rugby) – uncapped
23. Ava Wereta - #233 (Queensland Reds/Coomera Crushers) – 2 caps
*denotes possible debut