After a two-year absence, Louis Rees-Zammit was recalled to a 39-strong Wales squad unveiled Tuesday by new coach Steve Tandy.
The British and Irish Lions winger, who won the last of his 32 caps at the 2023 World Cup, made the switch to American Football in January 2024.
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The 24-year-old Bristol player joined the Kansas City Chiefs and then the Jacksonville Jaguars, but did not play a competitive game in the NFL.
His inclusion is a boost for Tandy as he named his squad for November Tests on successive weekends against Argentina, Japan, New Zealand and world champions South Africa.
"It's been really exciting going through the whole process and realising how many good players we've got," said Tandy, who left his role as Scotland defence coach - a position he had held since 2019 - to fill a vacancy created by Warren Gatland's departure in February.
"There's a really good mix of some young guys coming in, mixed with some experience as well. But the overall feeling is really exciting and I can't wait to get the boys into camp on Monday."
Jac Morgan will captain the squad for the campaign, having been on tour with the British and Irish Lions this summer in Australia. Fellow Lion Tomos Williams is also selected for Wales this autumn.
Meanwhile, Edinburgh captain Magnus Bradbury was recalled to the Scotland squad announced Tuesday for next month's Autumn internationals, three years after winning his last cap.
The 30-year-old back-row, who made the last of his 19 Test appearances in 2022, was included in a 45-man squad named by coach Gregor Townsend for November matches at Murrayfield against the United States, New Zealand, Argentina and Tonga.
Captain Sione Tuipulotu was also recalled after missing the Six Nations through injury and then being involved in the British and Irish Lions' series win over Australia.
Uncappped Montpellier back-rower Alexander Masibaka has retained his place after going on the summer tour of the South Pacific.
Backs: Josh Adams, Jacob Beetham, Rio Dyer, Dan Edwards, Jarrod Evans, Kieran Hardy, Joe Hawkins, Louie Hennessey, Max Llewellyn, Reuben Morgan-Williams, Blair Murray, Louis Rees-Zammit, Tom Rogers, Callum Sheedy, Ben Thomas, Nick Tompkins, Tomos Williams
Forwards: Keiron Assiratti, Adam Beard, Liam Belcher, Rhys Carre, Ben Carter, Brodie Coghlan, Christian Coleman, Rhys Davies, Taulupe Faletau, James Fender, Archie Griffin, Dafydd Jenkins, Dewi Lake, Alex Mann, Jac Morgan (capt), Morgan Morse, Taine Plumtree, Nicky Smith, Danny Southworth, Gareth Thomas, Freddie Thomas, Aaron Wainwright
Backs: Fergus Burke, Jamie Dobie, Darcy Graham, Adam Hastings, Rory Hutchinson, George Horne, Tom Jordan, Blair Kinghorn, Stafford McDowall, Kyle Rowe, Arron Reed, Finn Russell, Ollie Smith, Kyle Steyn, Ross Thompson, Sione Tuipulotu (capt), Duhan van der Merwe, Ben White
Forwards: Ewan Ashman, Josh Bayliss, Magnus Bradbury, Gregor Brown, Scott Cummings, Rory Darge, Jack Dempsey, Matt Fagerson, Zander Fagerson, Grant Gilchrist, Patrick Harrison, Nathan McBeth, Alexander Masibaka, Liam McConnell, Elliot Millar Mills, Harri Morris, Andy Onyeama-Christie, D'Arcy Rae, Dylan Richardson, Jamie Ritchie, Alex Samuel, Pierre Schoeman, Rory Sutherland, Marshall Sykes, George Turner, Murphy Walker, Max Williamson
