LIVE: The Springboks are holding a 20-10 lead over the Wallabies at half-time in Cape Town.
Joe Schmidt's team are riding high following their comeback win at Ellis Park, breaking a drought that spanned over 60 years.
Former Sevens star Corey Toole comes into the starting side for his Test debut, with Fraser McReight named as captain.
Rob Valetini also makes his return from injury, slotting in at the back of the scrum.
As for the hosts, they have made widespread changes, including the return of Cheslin Kolbe and Jesse Kriel's appointment as skipper.
FOLLOW ALL THE ACTION IN THE LIVE BLOG BELOW OR THE MATCH CENTRE
20-10 Springboks: James O'Connor's long range penalty just has the legs as the Wallabies go into the break down 10.
O'Connor's effort from 45 metres is a bullet as it finds its way over the cross-bar
20-7 Springboks: Kwagga Smith nabs a crucial try for the hosts as they extend the lead.
The number eight was a late inclusion and makes good use of the rare start, beating two defenders to dive over.
13-7 Springboks: The Springboks are finding further success in the aerial game as they hunt for another try.
It takes a clutch turnover from Corey Toole to save the Wallabies, who are dealing with Taniela Tupou on the ground with a finger injury.
13-7 Springboks: Both sides find themselves in a midfield battle as the Wallabies push for a response.
The hosts are intent on sticking with the kicking battle and getting mixed results.
13-7 Springboks: The Wallabies are keeping the pressure on as they go toe-to-toe with the hosts.
James O'Connor once again kicks for touch as he finds the line close to the try-line as the South Africans turn them over.
13-7 Springboks: Fraser McReight has made his first big call as captain as he opts for the line despite the kickable penalty.
It gives the Wallabies the chance to launch just outside the 22, only for the hosts to produce the pilfer penalty.
13-7 Springboks: Fraser McReight looked to have scored but the TMO brings it back for a tight knock-on.
An excellent tackle from Andrew Kellaway forces the mistake but it just clips his hand as it comes out, denying McReight the try after an excellent pick-up from the captain.
13-7 Springboks: Canan Moodie dives over as the hosts answer back.
A sharp, flat kick from Handre Pollard beats Corey Toole and the winger dives over.
During the break, Nic White has come off for Tate McDermott.
7-6 Wallabies: What a debut for Corey Toole as the winger has the opener.
Some smarts from Nic White off the free kick as the scrumhalf grubbers for his pacey winger, who collects and touches down.
6-0 Springboks: Handre Pollard makes it two from two as the hosts build scoreboard pressure.
Pollard nails it from 40 metres out despite the greasy conditions.
3-0 Springboks: Wallabies fullback Tom Wright is getting treatment on his knee and has come from the field.
Wright is downfallen as he comes from the field, with Andrew Kellaway replacing him.
A mistake from the Wallabies gives the Springboks another chance to strike just inside Australia's half, winning the scrum penalty.
3-0 Springboks: Handre Pollard adds first points as he nails an easy three points.
Joseph-Aukuso Suaalii is pinged for sealing off the ruck and Pollard makes no mistake.
The anthems have been sung and the game is underway in Cape Town.
A solid crowd in the house at DHL Stadium, with the rain holding off for now by the looks of it.
The South African anthem is belted out by the crowd, who feel the importance of this game.
Tries: Moodie, Smith
Cons: Pollard 2/2
Pens: Pollard 2/2
Tries: Toole
Cons: O'Connor 1/1
Pens: O'Connor 1/1
The Springboks have been forced into a late change due to illness, losing Jean-Luc du Preez.
Kwagga Smith takes his place in the starting side, with centre/flanker Andre Esterhuizen onto the bench.
Welcome to Rugby.com.au's coverage of the Wallabies taking on the Springboks in Cape Town.
Australian Rugby has already started the day strong with a Wallaroos thumping win over Samoa, with the Wallabies out to follow in their lead.
The Springboks have made a late switch during the week, with Aphelele Fassi in at fullback
WALLABIES (15-1): Tom Wright; Max Jorgensen, Joseph-Aukuso Suaalii, Len Ikitau, Corey Toole; James O'Connor, Nic White; Rob Valetini, Fraser McReight (captain), Tom Hooper; Will Skelton, Nick Frost; Taniela Tupou, Billy Pollard, Tom Robertson.
Replacements: Brandon Paenga-Amosa, Angus Bell, Zane Nonggorr, Jeremy Williams, Nick Champion de Crespigny, Tate McDermott, Tane Edmed, Andrew Kellaway.
SPRINGBOKS (15-1): Aphelele Fassi; Canan Moodie, Jesse Kriel (captain), Damian de Allende, Cheslin Kolbe; Handre Pollard, Grant Williams; Kwagga Smith, Franco Mostert, Marco van Staden; Ruan Nortje, RG Snyman; Thomas du Toit, Malcolm Marx, Ox Nche
Replacements: Marnus van der Merwe, Boan Venter, Wilco Louw, Eben Etzebeth, Lood de Jager, Andre Esterhuizen, Cobus Reinach, Sacha Feinberg-Mngomezulu,
Referee: James Doleman (NZR)
Assistant Referees: Andrew Brace (IRFU) & Gianluca Gnecchi (FIR)
TMO: Richard Kelly (NZR)
FPRO: Tual Trainini (FFR)
The Wallabies' clash with the Springboks in Cape Town will be shown LIVE on Stan Sport
Coverage will be live and ad-free on Stan Sport, slated to start at 12:30 am AEST with kickoff expected at 1:10 am AEST.