The Wallabies will kick-off the Rugby Championship as they face the defending champion Springboks at Ellis Park.
Joe Schmidt's side enters the clash with confidence after defeating the British & Irish Lions in Sydney.
Veteran James O'Connor starts in the gold jersey for the first time since 2022, with Tane Edmed a late addition to the bench.
Meanwhile, the South Africans are looking to continue an unbeaten record against the Aussies at Ellis Park that stretches back to 1963.
Captain Siya Kolisi will start his first game at number eight in the Springbok colours.
FOLLOW ALL THE ACTION IN THE LIVE BLOG BELOW OR THE MATCH CENTRE
WALLABIES (15-1): Tom Wright; Max Jorgensen, Joseph Aukuso-Suaalii, Len Ikitau, Dylan Pietsch; James O'Connor, Nic White; Harry Wilson (capt), Fraser McReight, Tom Hooper; Will Skelton, Nick Frost; Taniela Tupou, Billy Pollard, James Slipper
Replacements: Brandon Paenga-Amosa, Angus Bell, Zane Nonggorr, Jeremy Williams, Langi Gleeson, Tate McDermott, Tane Edmed, Andrew Kellaway
SPRINGBOKS (15-1): Aphelele Fassi; Edwill van der Merwe, Jesse Kriel, Andre Esterhuizen, Kurt-Lee Arendse; Manie Libbok, Grant Williams; Siya Kolisi (capt), Pieter-Steph du Toit, Marco van Staden; Lood de Jager, Eben Etzebeth; Wilco Louw, Malcolm Marx, Ox Nche
Replacements: Bongi Mbonambi, Jan-Hendrik Wessels, Asenathi Ntlabakanye, Franco Mostert, Kwagga Smith, Cobus Reinach, Canan Moodie, Damian Willemse
Referee: Ben O’Keeffe (NZR)
Assistant Referees: James Doleman (NZR) & Gianluca Gnecchi (FIR)
TMO: Tual Trainini (FFR)
FPRO: Richard Kelly (NZR)
The Wallabies' clash with the Springboks will be shown LIVE on Stan Sport
Coverage will be live and ad-free on Stan Sport, slated to start at 12:30 am AEST with kickoff expected at 1:10 am AEST.