Experienced centre Jonathan Davies has been ruled out of the Wales team to face the Wallabies.
Davies pulled up sore in the lead-up to the match, with a tight hmstring ultimately forcing his withdrawal.
The injury changes the dynamic considerably in Cardiff, breaking up one of the the most experienced Welsh midfield partnership, in a match up against Australia's fledgling duo of Tevita Kuridrani and Reece Hodge.
Scarlets' Scott Williams will come into the starting team for Davies, notching his 39th Welsh cap on Saturday.
Australia takes on Wales at Millennium Stadium, kicking off at 1:30am AEDT on Sunday, with the match LIVE on beIn Sports (Fotel Channel 515) and streamed on beIn Connect and Foxtel Go for Foxtel subscribers.