Macquarie Uni and Griffith Uni sit on top of their pools after day one in Hobart.
The two unis are the only undefeated sides in the competition after the opening four rounds and have sent a big message to the rest of the competition.
Macquarie inflicted UQ's first defeat in the history of the Uni 7s competition in their final game of the day, stamping themselves as the team to beat.
Griffith cruised through the first Pool B matches with wins over the University of Canberra and Sydney Uni.
Here's how the day unfolded.
4:35pm - Round four
Macquarie Uni has sprung the surprise of the tournament, ending UQ's undefeated run through the entire history of the Uni 7s.
UQ won every 2017 tournament undefeated and looked like continuing that run this season until they hit Macquarie in round four, losing 21-7.
UTas earned its first win of the day in round four as well, beating Melbourne Uni 26-12.
Griffith Uni will finish the day on top of Pool B after a win over UNE in round four.
Bond Uni finished the day with a win over UC to round out the opening fixtures in Hobart.
Round five kicks off at 9am AEST Sunday, with every game LIVE and FREE on RUGBY.com.au.
Melbourne Uni 12 - UTas 26
Macquarie Uni 21 - UQ 7
UNE 17 - Griffith 20
Bond Uni 22 - UC 10
2:26pm - Round three
The University of Adelaide is a surprise leader in Pool A after three matches.
South Australia's side claimed its second win of the day, cruising past hosts the University of Tasmania 26-12 after beating Melbourne Uni earlier.
Defending champions UQ are also on two wins sitting in second in the pool but have a game in hand after their bye in round two.
Sydney Uni notched a second straight victory in pool B and Griffith turned around a slow start to beat UC easily.
University of Adelaide 26 - UTas 12
Melbourne Uni 0 - UQ 46
UNE 10 - Sydney Uni 22
Griffith 30 - UC 0
12:25pm - Round two
Round two in Tasmania threw up some surprises and some nail biters.
Sydney Uni notched a maiden Uni 7s win in round two of the Hobart leg, surprising Bond Uni 32-0.
Jakiya Whitfield has been a standout for the Sydneysiders and she scored a spectacular hat-trick on the way to their first win.
Macquarie Uni sits on top of pool A with a perfect record so far, though UQ has a game in hand after a round two bye.
It took UC until after full-time to snatch a thrilling 24-19 win over UNE in the final match of the round.
The Canberrans took a turnover in the final minute and peppered the UNE line until they finally dotted down in the 15th minute.
UTas 0 - Macquarie Uni 25
Melbourne Uni 5 - University of Adelaide 31
Sydney Uni 32 - Bond Uni 0
UC 24 - UNE 19
10:30am - Round one
UQ and Macquarie Uni picked up where they left off in the opening round of 2018, with both competition heavyweights posting first-up wins.
Uni of Adelaide showed signs of a much-improved team in their tight loss to Macquarie.
Griffith Uni have quickly established themselves as the team to beat in Pool B after a 26-12 win over competition debutants Sydney Uni.
Bond Uni edged out UNE in the other Pool B match, winning 15-12.
Macquarie Uni 17 - Uni of Adelaide 7
UTas 5 - UQ 39
Bond Uni 15 - UNE 12
Sydney Uni 12 - Griffith Uni 26
Sunday August 26
9am - Macquarie Uni vs Melbourne Uni
9:20am - UQ vs University of Adelaide
9:40am - Griffith vs Bond Uni
10am - UC vs Sydney Uni
Macquarie Uni Rays
Maddison Anderson ©
University of Adelaide Romas
Ellie Konopka ©
Lauren Potter ©
University of Canberra
Sammie Wood (c)
University of Melbourne
Annie Buntine ©
Tangata Tupou ©
Jessika Elliston (Captain)
University of Tasmania
Lauryn Cooper (C)
Molly Baxter (VC)
Marioulla Belessis (vc)
Jannicke lJdens (c)
Hagiga (Haj) Mosby
Mackenzie Sadler (vc)
Bodil Van Wijnbergen
Terri-Anne Egan (13th)
University of New England
Tahlia goldsmith (c)
University of Sydney
Tilly Vaughan Fowler
Barbara Waddell (VC)
Liv White (C)
Freya Clayhill (VC)